منابع مشابه
Acetylcholine Receptors
The number of extrajunctional acetylcholine receptors ((125)I-labeled alpha-bungarotoxin binding sites) per unit length of muscle fiber and the average fiber circumference were determined for rat diaphragm muscle fibers denervated 0, 2, 4, 7, 10, and 14 days. From these data receptor densities (sites per square micrometer of surface) were calculated. Values thus obtained were considerably lower...
متن کاملOrganization of Acetylcholine Receptors
The receptor-rich postsynaptic membrane of the elasmobranch electric organ was fixed by quick-freezing and then viewed by freeze-fracture, deep-etching, and rotary-replication . Traditional freeze-fracture revealed a distinct, geometrical pattern of shallow 8.5-nm bumps on the E fracture-face, similar to the lattice which has been seen before in chemically fixed material, but seen less clearly ...
متن کاملLocalization of Acetylcholine Receptors
In cultures of Xenopus myotomal muscle cells and spinal cord (SC) some of the nerve-muscle contacts exhibit a high density of acetylcholine receptors (AChRs [Anderson et al ., 1977, /. Physiol. (Loud.) . 268:731-756, 757-773]) and synaptic ultrastructure (Weldon and Cohen, 1979, /. Neurocytol . 8:239-259) . We have examined whether similarly specialized contacts are established when the muscle ...
متن کاملNicotinic acetylcholine receptors modulate osteoclastogenesis
BACKGROUND Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis. METHODS The presence of nAChR subunits as well as the in-vitro effects of nAChR agonists were investigated by ex vivo osteoclastogenesis assays, real-time polymerase chain reaction, Western blot and flow cytometry in murine bone marrow-de...
متن کاملAlzheimer's disease and acetylcholine receptors.
Cholinergic abnormalities, alongside senile plaques, neurofibrillary tangles, and extensive neuronal loss, are the major characteristics in Alzheimer's disease (AD). Both nicotinic and muscarinic acetylcholine receptors are decreased in AD, and it has been shown that the reduction in the number of acetylcholine receptors precedes other pathologic changes. Anti-cholinergic drugs induce amnesia, ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1972
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.60.3.248